Lorazepam is metabolised in the liver by conjugation into inactive lorazepam-glucuronide.

This medication may be habit-forming and should be used only by the person it was prescribed for. edit Other useSee also: Nonmedical benzodiazepine drug useLorazepam is also used for other purposes. S. If you have any of these conditions, you may need a dose adjustment or special tests to safely take Ativan. Lorazepam also has abuse potential; the main types of misuse are for recreational purposes or continued use against medical advice. But diazepam's high lipid solubility also means it does not remain in the vascular space but soon redistributes into other body tissues. Longer-term use, up to six months, does not result in further accumulation. Oral lorazepam, and other benzodiazepines, have a role in long-term prophylactic treatment of resistant forms of petit mal epilepsy, but not as first-line therapies, mainly because of the development of tolerance to their effects. The main pharmacological effects of lorazepam are the enhancement of the effects of GABA at the GABAA receptor. A similar lorazepam dose given intravenously will result in an earlier and higher peak serum level, with a higher relative proportion of unmetabolised (active) lorazepam.