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Some antidepressants, anti-epileptic drugs such as phenobarbital, phenytoin and carbamazepine, sedative antihistamines, opiates, antipsychotics and alcohol when taken with lorazepam may result in enhanced sedative effects. Lorazepam tablets and syrups are administered by mouth only. Lorazepam is sometimes used as an alternative to midazolam in palliative sedation. The intermediate oxime is then reacted with chloracetyl chloride, and upon heterocyclization 6-chloro-2-chlormethyl-4-(2′-chlorophenyl)quinazolin-3-oxide is formed. Such allegations may arise because of incomplete amnesia, disinhibition, and impaired ability to process cues. Due to the development of tolerance to the anticonvulsant effects, benzodiazepines are generally not recommended for long-term use for the management of epilepsy. Because of its relative long duration of residual effects (sedation, ataxia, hypotension, and amnesia), lorazepam premedication is best suited for hospital inpatient use. You may report side effects to FDA at 1-800-FDA-1088. 5 mg is also a significant dose reduction (in the UK, the smallest tablet strength is 1. The ease of addiction to Lorazepam, (the Ativan brand was particularly cited), and its withdrawal were brought to the attention of the British public during the early 1980s in Esther Rantzen's BBC TV series "That's Life!", in a feature on the drug over a number of episodes.