Lorazepam is metabolised in the liver by conjugation into inactive lorazepam-glucuronide.

Otherwise, management is by observation, including of vital signs, support and, only if necessary, considering the hazards of doing so, giving intravenous flumazenil. Benzodiazepine treatment should be discontinued as soon as possible via a slow and gradual dose reduction regimen. Catatonia with inability to speak is responsive and sometimes controlled with a single 2 mg oral, or slow intravenous dose of lorazepam. It is also used as adjunct therapy for cyclic vomiting syndrome. Hydrolysis of thee above product forms the desired product lorazepam. This list is not complete and there may be other drugs that can interact with Ativan. Your doctor may occasionally change your dose to make sure you get the best results from this medication. Therefore, lorazepam's anticonvulsant effects are more durable, thus reducing the need for repeated doses. Due to tolerance and dependence, lorazepam is recommended for short-term use, 2–4 weeks only. What other drugs will affect Ativan?Before taking Ativan, tell your doctor if you are using any of the following drugs:* a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton); * an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate); * medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), haloperidol (Haldol), mesoridazine (Serentil), pimozide (Orap), or thioridazine (Mellaril); * narcotic medications such as butorphanol (Stadol), codeine, hydrocodone (Lortab, Vicodin), levorphanol (Levo-Dromoran), meperidine (Demerol), methadone (Dolophine, Methadose), morphine (Kadian, MS Contin, Oramorph), naloxone (Narcan), oxycodone (OxyContin), propoxyphene (Darvon, Darvocet); or * antidepressants such as amitriptyline (Elavil, Etrafon), amoxapine (Asendin), citalopram (Celexa), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), paroxetine (Paxil), protriptyline (Vivactil), sertraline (Zoloft), or trimipramine (Surmontil).