* Paradoxical effects: In some cases, there can be paradoxical effects with benzodiazepines, such as increased hostility, aggression, angry outbursts, and psychomotor agitation.

Patients should not be discharged from the hospital within 24 hours of receiving lorazepam premedication, unless accompanied by a caregiver. On regular administration, maximum lorazepam serum levels are attained after three days. Rebound effects often resemble the condition being treated but typically at a more intense level and may be difficult to diagnose. In cases of a suspected lorazepam overdose, it is important to establish whether the patient is a regular user of lorazepam or other benzodiazepines, since regular use causes tolerance to develop. Side effects such as sedation and unsteadiness increased with age. This medication can cause birth defects in an unborn baby. These effects are seen as more common with lorazepam than other benzodiazepines. Lorazepam is a different case: Its low lipid solubility makes it relatively slowly absorbed by any route other than intravenously, but once injected will not get significantly redistributed beyond the vascular space. It is given before a general anaesthetic to reduce the amount of anaesthetic agent required, or before unpleasant awake procedures, such as in dentistry or endoscopies, to reduce anxiety, to increase compliance, and to induce amnesia for the procedure. Store Ativan at room temperature away from moisture, heat, and light.