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Lorazepam has relatively potent anxiolytic effects and its best-known indication is the short-term management of severe anxiety; the FDA advises against use of benzodiazepines such as lorazepam for longer than 2–4 weeks. * Liver or kidney failure – Lorazepam may be safer than most benzodiazepines in patients with impaired liver function. Intravenous injections should be given slowly and patients closely monitored for side effects, such as respiratory depression, hypotension, or loss of airway control. If shown sympathy, even quite crudely feigned, patients may respond solicitously, but they may respond with disproportionate aggression to frustrating cues. Before taking Ativan, tell your doctor if you have any breathing problems, glaucoma, kidney or liver disease, or a history of depression, suicidal thoughts, or addiction to drugs or alcohol. You may need to use less and less before you stop the medication completely. 4%). Lorazepam-glucuronide is eventually excreted by the kidneys, and, because of its tissue accumulation, it remains detectable - particularly in the urine - for substantially longer than lorazepam. Lorazepam is sometimes used for individuals receiving mechanical ventilation. Pure lorazepam is an almost white powder that is nearly insoluble in water and oil.