Lorazepam has strong sedative/hypnotic effects, and the duration of clinical effects from a single dose makes it an appropriate choice for the short-term treatment of insomnia, in particular in the presence of severe anxiety.

Valproate, inhibits the metabolism of lorazepam, whereas carbamazepine, lamotrigine, phenobarbital, phenytoin, rifampin increases the rate of metabolism of lorazepam. The resulting benzodiazepin-4-oxide undergoes acetylation by acetic anhydride at the secondary nitrogen atom, and is further hydrolyzed by hydrochloric acid into 7-chloro-5-(2′-chlorophenyl)-1,2- dihydro-3H-1,4-benzodiazepin-2-on-4-oxide. Side effects such as sedation and unsteadiness increased with age. Lorazepam-glucuronide is eventually excreted by the kidneys, and, because of its tissue accumulation, it remains detectable - particularly in the urine - for substantially longer than lorazepam. Patients should not be discharged from the hospital within 24 hours of receiving lorazepam premedication, unless accompanied by a caregiver. It may further reduce the patient's ability to protect his or her airway during sleep. Ativan should never be shared with another person, especially someone who has a history of drug abuse or addiction. Regular lorazepam use during late pregnancy (the third trimester), carries a definite risk of benzodiazepine withdrawal syndrome in the neonate. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Be careful if you drive or do anything that requires you to be awake and alert.